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First Reliance Bank

Florence (Main Branch)

First Reliance Bank Florence BranchFirst Reliance Bank has two locations in Florence to serve customers. Florence is also our corporate headquarters. Our main branch is located at 2170 West Palmetto Street and offers clients a wide variety of personal and business banking services. Florence is at the heart of the Pee Dee region of South Carolina and is known for its citizens’ hospitality and welcoming ways.

The banking professionals at First Reliance Bank in Florence strive to reflect that attitude as well. Whether you’re interested in opening a personal banking account, applying for a mortgage in Florence to buy a home, or interested in a business loan to achieve your dream job, our representatives will be here to greet you with a smile.

Historically Florence has been known as a major hub for both industry and infrastructure with a focus on business, finance, and medicine. Florence also benefits from its geographic location in regards to the interstate system– it sits halfway between Miami and New York on I-95 and is a starting point of I-20, which runs from Florence to Atlanta, GA. This unique location has allowed Florence to attract major corporations including Honda, QVC, and Otis Elevator.

Florence has experienced a fantastic growth spurt over the last decade and offers a burgeoning downtown area with numerous options for entertainment, dining, and nightlife. Several highlights of the recent downtown revitalization efforts include:

  • The Florence Museum of Art, History & Science
  • Drs. Bruce and Lee Foundation Library
  • The Florence Little Theater
  • The Francis Marion University Performing Arts Center.

Services Offered:

  • Drive Thru ATM
  • Drive Thru Teller
  • Night Deposit
  • Safe Deposit Boxes
  • Personal Banking
  • Business Banking
  • Mortgage Banking
  • Investments & Insurance
  • People Management
  • Corporate Offices


2710 West Palmetto St.
Florence, SC 29501


Office: 843.656.5000
Fax: 843.662.8373

Lobby Hours:

Mon – Friday: 8:00 am – 6 pm
Saturday: 8:00 am – 4 pm

Drive-Thru Hours:

Mon – Friday: 8:00 am – 8 pm